MENDS2
In mechanically ventilated adults with sepsis, does the use of dexmedetomidine, compared with propofol, for continuous sedation improve the number of days alive without delirium or coma?
Continue reading »Tag: Pharmacology
DEXA-ARDS
In patients with moderate-severe ARDS, does dexamethasone in addition to routine care, compared with routine care alone increase ventilator free days up to day 28?
Continue reading »VIOLET
In critically ill patients with Vitamin D deficiency and a high risk of death, does early enteral replacement of Vitamin D3 compared with placebo improve survival at 90 days?
Continue reading »Hung
In adult patients with COVID-19, does combined interferon beta-1b, lopinavir-ritonavir, and ribavirin, compared with lopinavir-ritonavir alone, reduce the time to a negative swab result?
Continue reading »Wang
Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial Wang Y. Lancet; Epub Ahead of Print. doi: https://doi.org/10.1016/S0140-6736(20)31022-9 Clinical Question In patients with severe COVID-19, does intravenous remdesivir, compared with placebo, improve the time to clinical improvement? Background Despite the ongoing research efforts to find a treatment for patients infected with SARS-CoV-2, there are currently no proven […]
Continue reading »LOTUS China
In patients infected with SARS-CoV-2, what is the efficacy and safety of oral lopinavir–ritonavir?
Continue reading »COLCOT
In patients post myocardial infarction, does low dose colchicine compared with placebo, reduce ischaemic cardiovascular events?
Continue reading »EXTEND
In patients with acute ischaemic stroke, with salvageable brain tissue, does alteplase compared with placebo, administered between 4.5 – 9 hours post stroke onset, improve functional outcome at 90 days?
Continue reading »SUP-ICU
In ICU patients at risk of gastrointestinal (GI) bleeding does the use of prophylactic proton-pump inhibitor (PPI) compared to placebo reduce mortality at 90 days?
Continue reading »EXTEND IA TNK
In patients with anterior circulation strokes undergoing endovascular thrombectomy, is IV thrombolysis within 4.5 hours of stroke onset with tenecteplase, non-inferior to alteplase, at establishing reperfusion?
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