TELSTAR
In comatose survivors of cardiac arrest does the treatment of rhythmic and periodic electroencephalographic (EEG) patterns improve neurological outcome compared with standard care?
Continue reading »Tag: Neurology
COBI
In adult patients with moderate to severe traumatic brain injury, does a continuous infusion of 20% saline, compared with standard care along, improve neurological outcomes at six months?
Continue reading »ULTRA
In adults presenting with subarachnoid haemorrhage (SAH), does ultra early short term treatment with tranexamic acid improve clinical outcome at 6 months?
Continue reading »CERTA
In critically ill patients with acute altered level of consciousness and no recent seizures, does continuous EEG (cEEG) compared to repeated routine EEG (rEEG) correlate with reduced mortality?
Continue reading »Dex-CSDH
In patients with chronic subdural haemorrhage, what effect does dexamethasone compared with placebo have on neurological outcome at 6 months?
Continue reading »Propanalol in severe TBI
Beta-Blocker Therapy in Severe Traumatic Brain Injury: A Prospective Randomised Controlled trial Hosseinali Khalili. World J Surgery 2020; 44:1844-1853. https://doi.org/10.1007/s00268-020-05391-8 Clinical Question In patients with severe traumatic brain injury, does the administration of Beta-Blockade, compared with standard care alone, improve in-hospital mortality? Background The main aim of neurocritical in the management of traumatic brain injury is to mitigate the burden […]
Continue reading »ESETT
In patients with status epilepticus who have been treated with benzodiazepines, is Levetriracetam, Valproate or Fosphenyoin more likely to lead to an absence of seizures and improved responsiveness at 60 minutes?
Continue reading »EXTEND
In patients with acute ischaemic stroke, with salvageable brain tissue, does alteplase compared with placebo, administered between 4.5 – 9 hours post stroke onset, improve functional outcome at 90 days?
Continue reading »MAPAS
Early Manipulation of Arterial Blood Pressure in Acute Ischemic Stroke(MAPAS):Results of a Randomized Controlled Trial Luiz Antonio Nasi. Neurocritical Care 2019; doi: https://doi.org/10.1007/s12028-018-0642-5 Clinical Question In adult patients presenting within 12 hours of an acute ischaemic stroke (AIS), which of three targeted and pre-specified systolic blood pressure (SBP) ranges results in an improved functional outcome at 90 days? Background Significant […]
Continue reading »TICH-2
In adults with acute, spontaneous intra-cerebral haemorrhage (ICH), does the administration of tranexamic acid (TXA) compared to a placebo improve functional status at 90 days?
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