Tag: Microbiology

ANTHARTIC

Prevention of Early Ventilator-Associated Pneumonia after Cardiac Arrest Francois et al. N Engl J Med 2019;381:1831-42. DOI: 10.1056/NEJMoa1812379 Clinical Question In post out-of-hospital cardiac arrest patients treated with targeted temperature management, does the use of empirical antibiotics prevent early ventilator-associated pneumonia? Background Rates of survival to hospital discharge and good neurological outcomes post out-of-hospital cardiac arrest (OOHCA) remain poor Despite […]

SoM

27 September 2019 Duncan Chambler Intensive Care Medicine Leave a comment

Contact precautions in single-bed or multiple-bed rooms for patients with extended-spectrum Beta-lactamase-producing enterobacteriaceae in Dutch hospitals Kluytmans-van den Bergh. Lancet Infectious Diseases 2019; Published online 23rd August 2019. doi: 10.1016/S1473-3099(19)30262-2. Clinical Question In non-ICU, non-haematology patients that have been identified as carriers of extended-spectrum beta-lactamase-producing enterobacteriaceae (ESBLs), is a strategy of contact precautions in a multiple-bed room compared to contact […]

INSTINCT

26 May 2017 Ben Harris Emergency Medicine, Intensive Care Medicine One comment

In patients with necrotising soft tissue infection (NSTI), does the use of intravenous immunoglobulin (IVIG) compared to placebo improve patient reported physical outcomes?

EMPIRICUS

19 May 2017 Segun Olusanya Intensive Care Medicine One comment

In non-neutropenic critically ill patients with sepsis, multiple Candida colonisation, and multiple organ failure exposed to broad-spectrum antibacterials, does empirical micafungin therapy compared to placebo increase invasive fungal infection-free survival at day 28?

Talan

27 January 2017 Anthony Hackett Emergency Medicine Leave a comment

In patients with drained cutaneous abscesses does trimethoprim-sulfamethoxazole compared with placebo increase clinical cure rates?

Uranga

20 January 2017 Fraser Magee Emergency Medicine, Intensive Care Medicine Leave a comment

In hospitalised patients with community-acquired pneumonia (CAP), is five days of antibiotic therapy non-inferior to standard practice with respect to clinical improvement?

BLISS

22 January 2016 Adrian Wong Intensive Care Medicine 3 comments

In adult ICU patients with severe sepsis does the use of continuous infusion (CI) of beta-lactam antibiotics compared to intermittent bolus (IB) improve clinical outcomes?

APPAC

15 January 2016 John Kiely Peri-operative Medicine 2 comments

In patients presenting with acute uncomplicated appendicitis, is antibiotic therapy non-inferior to appendicectomy surgery?

PRORATA

4 December 2015 Duncan Chambler Intensive Care Medicine Leave a comment

In adult patients with suspected bacterial infections, does procalcitonin-guided antibiotic care compared to usual care reduce patient exposure to antibiotics without increasing mortality?

3Sites

30 October 2015 Adrian Wong Emergency Medicine, Intensive Care Medicine, Peri-operative Medicine One comment

In intensive care patients who require a central venous catheter (CVC), does the choice of insertion site affect the complication rates?

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