A compendium of critical appraisals in Intensive Care Medicine research and related specialties
In patients with large cerebral infarction volumes does the use of endovascular therapy alongside medical care compared with medical care alone improve 90-day functional outcomes?
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In neonates undergoing elective endotracheal intubation, does nasal high-flow therapy compared with standard care, improve 1st pass success without physiological instability?
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In patients admitted to ICU with severe diffuse traumatic brain injury (TBI) and refractory raised intracranial pressure (ICP), does early decompressive craniectomy improve functional outcomes when compared with continued medical management?
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In patients with trauma-related haemorrhagic shock does prehospital administration of packed red cells and lyophilised plasma (Lyo-Plas) compared with normal saline reduce the composite outcome of mortality and failure to reach lactate clearance?
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In patients with a witnessed refractory out-of-hospital cardiac arrest (OHCA) does early intra-arrest transport, extracorporeal CPR (ECPR) and invasive assessment improve neurological outcome at 180 days?
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In comatose survivors of cardiac arrest does the treatment of rhythmic and periodic electroencephalographic (EEG) patterns improve neurological outcome compared with standard care?
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In relatives of patients dying in the ICU, does a 3 step support strategy compared with standard care reduce prolonged grief disorder?
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Terminal QRS distortion is present in anterior myocardial infarction but absent in early repolarization Lee. @smithECGBlog. The American Journal of Emergency Medicine;2016;34(11):2182-2185 Clinical Question In patients with benign early repolarisation, is there the absence of terminal QRS distortion on the ECG? Background For patients who present with chest pain, it can be difficult to distinguish between ECG findings of benign […]
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In patients undergoing elective neurosurgery, is a supraclavicular in-plane ultrasound guided approach, compared with an infra-clavicular out-of-plane ultrasound guided approach, non-inferior for catheterisation-related complication?
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Balanced Multielectrolyte Solution versus Saline in Critically Ill Adults Finfer S, NEJM, 2022; DOI: 10.1056/NEJMoa2114464 Clinical Question In critically ill adults does the use of a balanced multielectrolyte solution (BMES, Plasmalyte 148), as opposed to 0.9% Sodium Chloride, for fluid resuscitation and therapy result in reduced 90 day mortality? Background Fluid administration is a key component of critical care therapy […]
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