Patel
In patients with acute respiratory distress syndrome (ARDS), does the use of non-invasive ventilation (NIV) delivered by helmet compared to NIV delivered by face mask reduce the need for intubation?
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OXYGEN-ICU
In critically ill adults, does conservative oxygen therapy compared to liberal oxygen therapy reduce mortality?
Continue reading »HYPRESS
In patients with severe sepsis does hydrocortisone compared to placebo prevent the development of septic shock?
Continue reading »LeoPARDS
In adult patients who have sepsis, does levosimendan reduce the incidence and severity of acute organ dysfunction compared with placebo?
Continue reading »CLASSIC
In ICU patients with septic shock who have had initial fluid resuscitation, what are the effects and feasibility of a protocol restricting further resuscitation fluid as opposed to standard care?
Continue reading »Grissa
In patients with acute pain in the Emergency Department, is acupuncture compared with intravenous morphine, more likely to reduce pain by >=50%?
Continue reading »PATCH
In patients with acute intracerebral haemorrhage, associated with antiplatelet therapy, does platelet transfusion compared with standard care reduce death or dependence?
Continue reading »van Lieshout
In critically ill patients requiring interhospital ground transport, is a nurse-led transfer team non-inferior to a physician-led team, for the proportion of patients with critical events?
Continue reading »RESCUEicp
In patients with a traumatic brain injury (TBI) and refractory intracranial hypertension, does decompressive craniectomy, result in more favourable mortality and neurological outcomes at 6 months, compared with barbiturate coma and continued medical management?
Continue reading »Philpot
Do observers of simulated family conversations discussing organ donation respond more favourably to the discussion if it contains extra information about the benefits of donation compared to a standard conversation?
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