DREAMS
In patients undergoing bowel surgery, does a single dose of dexamethasone compared against standard care reduce nausea and vomiting in the early post-operative period?
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Reconnect
In critically ill adult patients who pass a spontaneous breathing trial (SBT), does 1-hour rest compared with immediate extubation reduce re-intubation rates at 48 hours?
Continue reading »INPRESS
In high-risk patients undergoing surgical procedures, does a strategy of targeting individualised systolic blood pressure compared to standard practice reduce organ dysfunction
Continue reading »TRANSFUSE
In critically ill patients requiring transfusion, does the transfusion of the freshest available red cells compared to standard care impact on patient mortality?
Continue reading »ATACAS TXA
In adult patients undergoing elective coronary-artery surgery does tranexamic acid (TXA) compared to a placebo increase the risk of death or thrombotic complications within the first 30 days after surgery?
Continue reading »ATACAS Asp
In adults undergoing elective coronary artery graft surgery does the administration of aspirin prior to surgery compared to a placebo result in increased mortality or thrombotic complications?
Continue reading »DETO2X-AMI
In patients with suspected myocardial infarction with no baseline hypoxia, does oxygen therapy or room air improve all-cause mortality at 1 year?
Continue reading »60/60 sign for Acute PE
In patients with suspected acute pulmonary embolism, do echo features of disturbed right ventricular ejection allow accurate diagnosis?
Continue reading »Seymour
In patients with severe sepsis or septic shock, does a faster time to completion of a 3 hour bundle of care, compared with a slower time, affect in hospital mortality?
Continue reading »POISE 1
In patients undergoing non-cardiac surgery, do beta-blockers compared to placebo reduce the composite of death, MI or non-fatal cardiac arrest?
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