A compendium of critical appraisals in Intensive Care Medicine research and related specialties
In mechanically ventilated patients without acute respiratory distress syndrome (ARDS), does a low tidal volume ventilation strategy (6mL/Kg), compared to intermediate tidal volume strategy (10mL/Kg), reduce the number of ventilator-free and alive days at day 28?
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In delirious adult ICU patients, does the administration of haloperidol or ziprasidone reduce the duration of delirium when compared with placebo?
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In ICU patients at risk of gastrointestinal (GI) bleeding does the use of prophylactic proton-pump inhibitor (PPI) compared to placebo reduce mortality at 90 days?
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patients with septic shock and severe acute kidney injury, does early vs. delayed renal replacement therapy improve 90 day mortality?
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In patients with severe blunt traumatic brain injury (TBI) does early and sustained cooling compared with standard care improve neurological outcomes at 6 months?
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In adult patients with septic shock and high circulating endotoxin activity, does the use of polymyxin B haemoperfusion therapy significantly decrease 28-day mortality?
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In adult patients at risk of nausea and vomiting during surgery, do multiple antiemetic interventions compared to single antiemetic interventions or no intervention reduce nausea and vomiting?
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In adults suffering out-of-hospital non-traumatic cardiac arrest, does a strategy of airway management initially with laryngeal tube (LT) compared to endotracheal intubation (ETI) reduce mortality at 72 hours?
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In patients undergoing cardiac surgery, who have a moderate-to-high risk of death, does a restrictive transfusion strategy compared with a liberal strategy impact on a composite outcome of death, myocardial infarction, stroke and acute kidney injury requiring dialysis at 6 months after surgery?
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In patients presenting to the Emergency Department with suspicion for acute coronary syndrome (ACS), does the use of a high-sensitivity troponin assay reduce subsequent myocardial infarction or cardiovascular death at 12 months when compared with the use of a standard troponin assay?
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