A compendium of critical appraisals in Intensive Care Medicine research and related specialties
In adults with decompensated heart failure who are at high-risk of diuretic resistance, does furosemide administered by infusion compared to intermittent bolus increase the incidence of freedom from congestion at 72 hours?
Continue reading »
In obese patients, does the use of recruitment maneuvers with high PEEP, compared with low PEEP, decrease postoperative pulmonary complications?
Continue reading »
In adult critically ill patients with hypoxemic respiratory failure necessitating intubation, does high-flow nasal cannula (HFNC) compared to bag-valve-mask (BVM) for both pre-oxygenation and oxygenation during intubation reduce desaturation?
Continue reading »
In patients with cirrhosis and acute variceal bleeding, does early transjugular intrahepatic portosystemic shunt (TIPS) compared to standard care increase transplant-free survival?
Continue reading »
In patients with intermediate risk PE, do low doses of tPA and short durations of ultrasound facilitated catheter directed thrombolysis, result in a reduction in RV:LV diameter at 48 hours?
Continue reading »
In patients with moderate to severe ARDS, does a strategy of early neuromuscular blockade with heavy sedation, as opposed to usual care with lighter sedation targets, result in a lower 90 day mortality?
Continue reading »
In critically ill adults, does haloperidol 1 mg or haloperidol 2 mg given three times a day compared to placebo reduce mortality?
Continue reading »
In adult patients with sepsis-associated coagulopathy does the administration of human recombinant thrombomodulin (rhsTM) compared to placebo reduce 28 day mortality?
Continue reading »
Does titrating positive end-expiratory pressure (PEEP) with the use of an esophageal balloon to estimate pleural pressure improve outcomes compared with an empirical high PEEP –FiO2 strategy in patients with moderate – severe acute respiratory distress syndrome (ARDS)
Continue reading »
In patients with acute ischaemic stroke, with salvageable brain tissue, does alteplase compared with placebo, administered between 4.5 – 9 hours post stroke onset, improve functional outcome at 90 days?
Continue reading »