A compendium of critical appraisals in Intensive Care Medicine research and related specialties
A category to collect all the summaries, so that they can be used in menus and widgets. Please don’t expand this – “Specialties” and “Special Topics” have been created as a custom category sets for the clinical topics.
In patients with anterior circulation strokes undergoing endovascular thrombectomy, is IV thrombolysis within 4.5 hours of stroke onset with tenecteplase, non-inferior to alteplase, at establishing reperfusion?
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In patients with severe ARDS, does the early initiation of Extracorporeal Membrane Oxygenation (ECMO), compared to standard care, improve mortality at day 60?
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In septic and mechanically ventilated patients aged 50 or over, does 24 hours of induced hypothermia followed by 48 hours of normothermia improve 30-day mortality compared to routine care?
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In adult patients undergoing major elective abdominal surgery, does a restrictive fluid regimen compared with a liberal fluid regimen reduce complications and improved disability-free survival?
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In patients who are 6-24 hours post acute stroke, and have a mismatch between clinical deficit and infarct, does thrombectomy plus standard medical care, compared to standard medical care alone, improve functional outcomes at 90 days?
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In adult patients post out of hospital cardiac arrest does a continuous or on demand application of neuromuscular blockade (NMB) reduce the number of shivering episodes during targeted temperature management (TTM)?
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In peri-operative patients at low to moderate risk of post-operative complications, does goal-directed haemodynamic therapy using oesophageal doppler monitoring compared to standard care, reduce the incidence of post-operative complications within 180 days?
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In patients with status epilepticus (SE) and cluster attacks of seizures, (CS) does IV levetiracetam vs. IV phenytoin improve rate of control of seizures?
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In critically ill adults, does the administration of ramelteon compared to placebo reduce the length of intensive care stay?
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In post-operative patients requiring mechanical ventilation, does intensive insulin therapy compared to conventional insulin therapy reduce mortality?
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