ATESS
In patients with septic shock, does the use of intravenous vitamin C and thiamine compared to standard therapy improve recovery from organ failure?
Continue reading »Category: Intensive Care Medicine
A collection of TBL summaries relevant to Intensive Care Medicine
REMAP-CAP
In patients with severe COVID-19, does intravenous hydrocortisone (either as a fixed dose or restricted to when shock is clinically evident) compared with standard care, improve 21-day organ support free days?
Continue reading »LOCO2
In patients with acute respiratory distress syndrome (ARDS), does conservative vs. liberal oxygen reduce death at 28 days?
Continue reading »Propanalol in severe TBI
Beta-Blocker Therapy in Severe Traumatic Brain Injury: A Prospective Randomised Controlled trial Hosseinali Khalili. World J Surgery 2020; 44:1844-1853. https://doi.org/10.1007/s00268-020-05391-8 Clinical Question In patients with severe traumatic brain injury, does the administration of Beta-Blockade, compared with standard care alone, improve in-hospital mortality? Background The main aim of neurocritical in the management of traumatic brain injury is to mitigate the burden […]
Continue reading »GRECCO-19
In patients hospitalised with symptomatic coronavirus disease 2019, does the administration of colchicine improve clinical & laboratory outcomes?
Continue reading »STARRT-AKI
Standard versus Accelerated Initiation of Renal Replacement Therapy Wald R, Bagshaw S. NEJM July 16 2020 doi:10.1056/NEJMoa2000741 Clinical Question In critically ill patients with severe acute kidney injury, does accelerated initiation of renal replacement therapy compared to standard initiation improve 90 day survival? Background Acute Kidney Injury (AKI) is common in critically ill patients and some case series suggest up […]
Continue reading »RECOVERY: COVID-19 dexamethasone
In hospitalised patients with SARS-CoV-2 infection does dexamethasone in additional to usual care, compared to usual care alone, reduce 28-day mortality?
Continue reading »DIRECT-MT
In patients with acute anterior ischaemic stroke, is endovascular thrombectomy alone, compared with endovascular thrombectomy preceded by intravenous alteplase, noninferior with respect to modified Rankin score at 90 days?
Continue reading »Boulware
In people who have high-risk or moderate-risk exposure to someone with confirmed COVID-19 infection, does taking hydroxychloroquine following the exposure compared to placebo reduce the incidence of a new illness compatible with COVID-19?
Continue reading »VIOLET
In critically ill patients with Vitamin D deficiency and a high risk of death, does early enteral replacement of Vitamin D3 compared with placebo improve survival at 90 days?
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